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Identifying new medicines to treat Alzheimer's Disease through greater understanding of the APOE gene

Image by GerryShaw via Wikimedia Commons

"The role the APOE gene plays in the development of Alzheimer's Disease is not well understood and has largely been ignored to date"

Dr Margaretha Bakker, ADAPTED Project Leader


The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development)  project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function of the APOE gene. APOE is well known as a risk factor for developing the disease but precisely how this gene contributes to the risk of developing AD is not known.

ADAPTED brings together the expertise of researchers in universities, research institutes and biotech and pharmaceutical companies from across Europe and the USA. Using the expertise of the ADAPTED partners in a range of cutting-edge biological analysis methods the project will attempt to really unravel the complexities of the APOE gene as well as providing the research community with a new generation of human cell –based tools to mimic and investigate the causes and progression of the disease.

This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement number 115975. This Joint Undertaking received support from the European Union's Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations. The project runs from 1st October 2016 to 30th September 2019 and has an estimated budget of €6.8M

See our latest publications in academic journals, as well as titles of posters presented by ADAPTED Researchers.


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The ADAPTED consortium is committed to sharing data, analysis techniques, protocols and cell models.

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